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15 Likewise, free radicals have dual actions depending on their concentration

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This dual regulatory mechanism of SLC25A39 transporter, by AFG3L2 and iron, further advances our understandings of metabolic regulation through protein quality control and metabolite sensing, opening new avenues to explore the regulation of metabolic compartmentalization in cellular metabolism

Overall, this work proposed a convenient, safe, and effective rectal drug delivery strategy, providing a new candidate for the prevention and treatment of radiation-induced proctitis, and also providing a reference for the design of multifunctional local delivery systems in radiation-associated tissue injury